| Theme |
Regulation, disease states and drug targets of kidney tubular transporters -- Topics |
| Title |
Sodium transport and hypertension |
| Author |
Yuichi Inoue |
Department of Nephrology, Tokyo Medical and Dental University |
| Author |
Shinichi Uchida |
Department of Nephrology, Tokyo Medical and Dental University |
| [ Summary ] |
Increased Na-Cl absorption in the kidneys causes hypertension. Pseudohypoaldosteronism type 2 and Liddle's syndrome are hereditary hypertensive diseases characterized by increased Na-Cl reabsorption in the kidneys. Activation of the WNK-OSR1/SPAK-NCC cascade has been identified as the cause of hypertension in association with PHA II. This cascade is regulated by aldosterone and insulin. Impaired Nedd4-2 mediated ENac ubiquitination is identified as the cause of hypertension in Liddle's syndrome. This WNK-OSR 1/SPAK-NCC cascade is a potential target for anti-hypertensive drugs. |