| Theme |
Regulation, disease states and drug targets of kidney tubular transporters -- Topics |
| Title |
Na+-dependent Pi transporters and disease |
| Author |
Hiroko Segawa |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School |
| Author |
Saori Onishi |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School |
| Author |
Yuji Shiozaki |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School |
| Author |
Shohei Sasaki |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School |
| Author |
Ken-ichi Miyamoto |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School |
| [ Summary ] |
Serum phosphate levels are maintained within proper ranges by a process which involves the intestinal absorption and renal reabsorption of inorganic phosphates (Pi) via the sodium-dependent Pi (NaPi) transport system. They are also regulated by several factors, including 1,25 (OH) 2D, parathyroid hormone and FGF23. Recent studies have revealed that various factors (GALNT 3, Klotho, etc.) are related to FGF23. Furthermore, the association between a mutation in the NaPi transporters and inherited disease has been shown to be associated with Fanconi's syndrome (mutation in NaPi- 2a gene), hereditary hypophosphatemic rickets with hypercalciuria (mutation in the NaPi-2c gene), pulmonic alveolar microlithiasis (mutaion in the NaPi-2b gene), and familial idiopathic basal ganglia calcification (mutaion in the PiT-2 gene). |