| Theme |
Physiological roles of phosphorus in nutritional science |
| Title |
Intestinal phosphate absorption |
| Author |
Hiroko Segawa |
Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author |
Etsuyo Hanabusa |
Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author |
Tomo Mukai |
Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author |
Junya Furutani |
Department of Molecular Nutrition, University of Tokushima Graduate School |
| Author |
Ken-ichi Miyamoto |
Department of Molecular Nutrition, University of Tokushima Graduate School |
| [ Summary ] |
The current therapy for hyperphosphatemia in patients with chronic kidney disease (CKD) consists of dietary Pi restriction in combination with administration of Pi binders. However, problems exist with this treatment modality. Therefore, other therapeutic approaches to reduce serum Pi are needed. The sodium-dependent inorganic phosphate (NaPi) transport system is involved in intestinal Pi absorption and is regulated by several factors. Type IIb and type III transporters are expressed in the brush-border membrane in intestinal epithelial cells and transport Pi. Recent studies using knockout mice have demonstrated that NaPi2b is an important molecule for intestinal Pi absorption. Therefore, NaPi2b is considered to be a primary target for the developmental of hyperphosphatemia inhibitors. |