| Theme |
New evolution of vitamin D |
| Title |
Direct effects of vitamin D on bone metabolism |
| Author |
Tamaki Yamada |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author |
Hiromi Hongo |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author |
Muneteru Sasaki |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author |
Tomoka Hasegawa |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author |
Erika Akahori |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| Author |
Norio Amizuka |
Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University |
| [ Summary ] |
The new active vitamin D analog 1α,25-dihydroxy-2β-(3-hydroxypropyloxy) vitamin D, eldecalcitol, was developed for treatment of osteoporosis. Compared to alfacalcidol, an earlier form of active vitamin D analog, tests of patients who were administered eldecalcitol and animal models revealed a lower incidence of bone fractures and higher bone mineral density. Recent reports suggest models for the bone forming activity of eldecalcitol. This activity may be due to elevated alkaline phosphatase levels and the occurrence of mini-modeling in eldecalcitol-administered patients and animal models. Our recent findings suggest that eldecalcitol stimulates preosteoblastic differentiation into mature osteoblasts, which may induce mini-modeling or focal bone formation. |