| Theme |
Progress in the management of osteoporosis |
| Title |
Bone quality and collagen cross−links |
| Author |
Mitsuru Saito |
Department of Orthopaedic Surgery, Jikei University School of Medicine |
| Author |
Keishi Marumo |
Department of Orthopaedic Surgery, Jikei University School of Medicine |
| [ Summary ] |
Bone quality is considered to be related the structural and material properties of bone. Bone collagen crosslinking plays important roles in bone strength. We have demonstrated that the quantitative and qualitative deterioration of lysyl oxidase control and non enzymatic cross‒links (advanced glycation end products ; AGEs, pentosidine) of collagen in patients with osteoporotic femoral neck fracture and diabetes, and chronic kidney disease may be affected by increased oxidative stress, carbonyl stress, and glycaiton. Recently, we reported that a higher urinary pentosidine level was an independent risk factor for vertebral fractures in a 5‒year prospective study involving Japanese women. If confirmed in large prospective trials, measurements of serum homocysteine and serum or urine levels of pentosidine may be characterized as markers reflecting bone collagen deterioration. |