| Theme |
Magnesium and chronic kidney disease |
| Title |
Magnesium regulatory organs and regulatory mechanisms |
| Author |
Hiroshi Matsuzaki |
Department of Nutrition, Junior College of Tokyo University of Agriculture |
| Author |
Kazuharu Suzuki |
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture |
| [ Summary ] |
Magnesium is an essential mineral for living organisms, and plays an important role in many fundamental biological processes. The kidneys and bones are central effector organs for magnesium homeostasis. In regard to the effects of magnesium intake on regulatory organs such as the kidneys and bones, animal based experiments indicate that a magnesium-deficient diet leads to increased kidney Ca and P concentrations and increased development of nephrocalcinosis. Furthermore, magnesium deficiency has a marked effect on glomerular and tubular functions. It has been reported that magnesium intake is correlated with bone mineral content and/or bone mineral density. Magnesium-deficient diets induced a decrease in bone formation and an increase in bone resorption. This suggests that magnesium defi ciency impaires bone growth by an uncoupling of bone formation and bone resorption in rats. As a result, low magnesium intake may lead to serious changes in regulatory organs such as the kidneys and bones. In this paper, the relationship between magnesium intake and regulatory organs is reviewed. |