| Theme |
Lifestyle-related diseases and fracture risk |
| Title |
Increased risk of bone fractures in chronic kidney disease patients |
| Author |
Masaaki Inaba |
Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] |
Secondary hyperparathyroidism develops in patients with chronic kidney disease (CKD) due mainly to the accumulation of phosphate in the serum, leading to an increased risk of fractures at multiple sites. However, it has been increasingly recognized recently that the prevalence of fractures increases even in the early stages of CKD due mainly to impairment of bone quality, which is caused by several mechanisms including increased oxidative stress, malnutrition, and increased risk for fall due to muscle weakness. The frequent association of diabetes mellitus (DM) with CKD leads to further deterioration of bone quality, as we demonstrated by the increased incidence of DM hemodialysis patients independent of bone mineral density. |