| Theme |
Recent progress in calcium/phosphate metabolism and Klotho |
| Title |
Renal failure and Klotho |
| Author |
Manabu Ogura |
Department of Nephrology, Jichi Medical University |
| Author |
Kazuhiro Shiizaki |
Department of Nephrology, Jichi Medical University |
| Author |
Eiji Kusano |
Department of Nephrology, Jichi Medical University |
| [ Summary ] |
Recently, it has come to be widely known that chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. Moreover, some problems accompaning aging are also more significant in patients with CKD than in the normal population. It has been shown that the expression levels of the age controlling gene Klotho in the kidnies, which are the most remarkably Klotho-expressive organs, are significantly lower in patients with CKD and in animal models. This reduction may contribute to the progression of the above mentioned conditions however, details of related mechanisms have not beenclarified.
Klotho regulates not only calcium/phosphate metabolism but also the oxidation stress and insulin metabolism resulting in the amelioration of some problems related to CKD. Moreover, it has been reported in animal studies that Klotho gene transduction may reduce Angiotensin II-induced renal damage. Thus, Klotho is expected to be found to be one powerful regulator in the progression of CKD and various conditions of this type. |