| Series |
［Series］Case Report |
| Title |
Deterioration of renal function through hypercalcemia induced by vitamin D compound intoxication in CKD patients |
| Author |
Kunihiko Yoshiya |
Department of Nephrology, Hara Genito-urinary Hospital |
| Author |
Masafumi Kumano |
Department of Urology, Hara Genito-urinary Hospital |
| Author |
Shouji Hara |
Department of Urology, Hara Genito-urinary Hospital |
| Author |
Nobutoshi Oka |
Department of Urology, Hara Genito-urinary Hospital |
| [ Summary ] |
Six elderly CKD patients were given vitamin D compounds in relation to diagnoses of osteoporosis and lumbago. As a result, they developed hypercalcemia, and exhibited symptoms of aggravated renal function. Blood examination findings at initial diagnosis were BUN 48.1 mg / dl, Cr 301 mg / dl, Ca 12.7 mg / dl. In spite of slight abnormal urinary findings, renal dysfunction was grave. A characteristic of the diagnoses was the presence of hypercalcemia and renal dysfunction. After drug withdrawal, the laboratory findings were restored in BUN 21.6 mg / dl, Cr 1.55 mg / dl, Ca 9.6 mg / dl. The mechanism of renal function deterioration was regarded to be bypercalcemic nephropathy. Hypercalcemia was induced by vitamin D intoxication. At withdrawal of vitamin D compounds, hypercalcemia and renal dysfunction improved. It is necessary to note that there is a risk of exacerbated renal function in elderly CKD patients through administration of vitamin D compounds. |