| Theme |
Lipid metabolism and bone-vascular relationship |
| Title |
Bisphosphonate treatment for vascular calcification |
| Author |
Yosuke Okada |
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan |
| Author |
Osamu Hashimoto |
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan |
| Author |
Takahisa Tanikawa |
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan |
| Author |
Yoshiya Tanaka |
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan |
| [ Summary ] |
Severe atheroscierosis / calcinosis is frequently observed in aging, diabetes mellitus and chronic dialysis patients. This leads to cardiovascular events. Recent progress in basic research has revealed certain similarities between bone calcification processes and calcification of vascular tissues which contribute to several cardiovascular diseases. These findings extend the link between bone remodeling and vascular calcification, opening avenues for novel therapeutic strategies. However, the current evidence is not conclusive and further research is necessary to confirm these actions in clinical settings. |