| Theme |
New aspect of calcium, magnesium and phosphate transport -- Basic principles and clinical applications |
| Title |
Dietary promotion of intestinal calcium absorption and prevention of bone diseases |
| Author |
Hiroshi Hara |
Laboratory of Nutritional Biochemistry, Research Group of Food Science, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University |
| [ Summary ] |
Enhancement of calcium absorption rates in the intestines efficiently compensates for lower intakes of dietary calcium, which is usually absorbed at low rates. The mechanisms for increasing calcium absorption through dietary factors are first inhibiting formation of insoluble calcium salts in the small intestine, and secondly promotion of absorption in the large intestine through production of organic acids, which are enhanced by intestinal fermentation of nondigestible saccharides. Recently manufactured nondigestible disaccharide, difructose anhydrides III have been seen to increase calcium absorption via a paracellular pathway in the epithelial cell layer the small intestine. These nondigestible saccharides potentials effectively compensate for impaired calcium absorption brought on by renal failure or gastrectomy. Moreover, providing these food increase bone mineral density and bone strength in ovariectomized rats and normal rats, which experienced spontaneous running exercise. |