| Theme |
New aspect of calcium, magnesium and phosphate transport -- Basic principles and clinical applications |
| Title |
Roles of fibrobrast growth factor 23 and klotho on the regulation of type II sodium dependent phosphate transporters |
| Author |
Hiroko Segawa |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author |
Akemi Onizuka |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author |
Yuka Tomoe |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author |
Ken-ichi Miyamoto |
Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| [ Summary ] |
The present study demonstrated that hyperphosphatemia in kl / kl mice results from increased renal sodium-dependent Pi transporter activity and increased intestinal Pi absorption. Mutation of klotho causes an elevation in the type II a and type II c Na / Pi cotransporter proteins in the apical membrane, but this elevation cannot be explained by changes in FCF23, kl / kl mice may provide an important tool to study the roles of FGF23 in body Pi homeostasis. |