| Theme |
Glucocorticoid-induced osteoporosis and bone metabolism |
| Title |
Biphasic effects of glucocorticoid on bone metabolism : promotion of osteoblast differentiation and inhibition of bone formation |
| Author |
Keizo Ohnaka |
Department of Geriatric Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu University |
| Author |
Ryoichi Takayanagi |
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyusyu University |
| [ Summary ] |
Glucocorticoids (GCs) are essential for the maintenance of homeostasis. However, GCs in excess doses cause various adverse effects. GCs have biphasic effects on osteoblast function. Although GCs at physiological concentrations promote differentiation of mesenchymal stromal cells into osteoblasts, GCs at pharmacological doses suppress osteoblast function by such mechanisms as suppression of Cbfal expression, reduction in production of various growth factors, promotion of osteoblast apoptosis and suppression of bone formation signals including Wnt, leading to glucocorticoid-induced osteoporosis. |