| [ Summary ] |
Although there is a close relationship between parathyroid function and bone remodeling, it cannot necessarily be said there is enough accuracy with intact PTH assaies as a non-invasive diagnostic procedure for renal bone disease. These poor diagnostic abilities are observed, especially in adynamic bone disease, rather than with high bone turnover. This problem arises because there is skeletal resistance to PTH and the characteristics of intact PTH assaies measuring PTH fragments other than 1-84 PTH have unknown reactions with PTH. Whole PTH assaies that do not measure 7-84 make up for the lack of diagnostic ability for intact PTH with adynamic bone disease. Therefore, whole PTH assaies may reduce the clinical risk of iatrogenic adynamic bone conditions. |