| Theme |
A new aspect of vitamin D |
| Title |
Molecular mechanism of ligand induced transrepression by vitamin D receptors |
| Author |
Shigeaki Kato |
Institute of Molecular and Cellular Biosciences, The University of Tokyo / Japan Science and Technology Agency, ERATO |
| Author |
Ryoji Fujiki |
Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| Author |
Akiko Murayama |
Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| Author |
Hirochika Kitagawa |
Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| [ Summary ] |
Vitamin D exerts a variety of biological actions including mineral metabolism and bone remodeling. Most such vitamin D actions are believed to mediate transcriptional controls of a particular set of target genes through nuclear receptor, vitamin D receptors (VDR). The products of the genes regulated by VDRs are responsible for overt estrogen actions in the many estrogen target tissues. Ligand induced transcriptional controls through VDRs involve positive and negative gene regulations with co-regulator switching. Though the molecular basis of ligand induced transactivation by VDR has been extensively studied, and has been associated with identification of a number of co-regulator complexes, little is known about ligand induced transrepression. In the present review, we will describe a molecular basis for ligand-induced transrepression by VDR, as an example in the gene regulanon of vitamin D 1 alpha-hydroxylase. |