| Theme |
FGF23 as a regulatory factor of bone and mineral metabolism |
| Title |
FGF23 in tumor-induced osteomalacia |
| Author |
Yasuhiro Takeuchi |
Toranomon Hospital Endocrine Center |
| [ Summary ] |
FGF23 was identified as a causative factor for tumor-induced osteomalacia (TIO) in 2001. Recent research indicates that increased levels of circulating FGF23 are involved in the pathogenesis of hypophosphatemic osteomalacia other than TIO, such as X-linked hypophosphatemic rickets / osteomalacia. Accumulating evidence strongly suggests tbat FGF23 also plays a physiological role in phosphate and vitamin D metabolism and seems to be a hormone like molecule in circulation. Evaluation of circulating FGF23 level is now essential for diagnosis of TIO ; however, high serum FGF23 levels are not sufficient to lead to a diagnosis. Physicians should carefully evaluate other clinical features of their hypophosphatemic patients. Venous sampling for FGF23 may be useful to localize a tumor causing TIO that should be surgically removed. |