| Theme |
FGF23 as a regulatory factor of bone and mineral metabolism |
| Title |
Identification and biological activity of FGF23 |
| Author |
Takeyoshi Yamashita |
Pharmaceutical Research Laboratories, Pharmaceutical Division, KIRIN Brewery Co., Ltd. |
| [ Summary ] |
Several lines of studies on hypophosphatemic rickets / osteomalacia have suggested the presence of an unidentified phosphate regulating hormone termed “Phosphatonin”. The identification of the responsible gene for autosomal dominant hypophosphatemic rickets / osteomalacia and the cloning of a causative factor for tumor induced osteomalacia led to the same molecule, which had already been identified as one of the members of the FGF family, FGF23. Development of assay systems for FGF23 facilitates the understanding of the pathophysiological role of FGF23. Furthermore, recent advances in the exploration of the biological activity of recombinant FGF23 and in studies on Fgf23 KO mice have demonstrated that FGF23 plays important roles in the regulation of Na / Pi cotransporter and hydroxylases for vitamin D metabolites. In consequence, FGF23 is known as a novel regulatory factor for phosphate and vitamin D metabolism. |