| Theme |
The impact of bone and Ca/Pi metabolism on vascular disease |
| Title |
Cells and factors involved in vascular mineralization |
| Author |
Akira Yamaguchi |
Division of Oral Pathology and Bone Metabolism, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences |
| [ Summary ] |
Recently, it has been reported that bone-related factors are involved in vascular calcification. Among bone matrix proteins, osteopontin and matrix Gla protein play important roles in vascular calcification. Several reports suggest that synthesis of these bone-related matrix is controled by regulatory factors for osteoblast differentiation including BMP and Cbfa 1. |