| Theme |
The impact of bone and Ca/Pi metabolism on vascular disease |
| Title |
Pathology of calcification in long term hemodialysis |
| Author |
Makio Kawakami |
Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author |
Hiraku Yoshida |
Department of Nephrology, Tokyo Jikei Medical University |
| Author |
Masafumi Suzuki |
Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author |
Toru Harada |
Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author |
Kaoru Iwabuchi |
Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author |
Keitaro Yokoyama |
Department of Nephrology, Tokyo Jikei Medical University |
| Author |
Yoshindo Kawaguchi |
Department of Nephrology, Tokyo Jikei Medical University |
| [ Summary ] |
The calcification of the cardiac valves, the coronary artery and the aorta were examined in 664 autospsy cases including dialysed, non-dialysed uremics and a control group. The following results were found: (1) the low correlation of BUN and creatinine in contrast to Ca and P favoring calcification, (2) high predisposition to intereferance by diabetic and hypertensive factors, (3) a significant effect on length of exposure to hypertension and dialysis became clear.
As to dialysis properties, we noted the following points: (4) initial ameriolation of heart load, eventually (after 6 years) resulted in severe decompensation, (5) a steady rise in blood Ca, and (6) periodic acceleration of calcification over 6 years, from long-term dialysis. These facts suggest that the bony and muscular site of dynamic Ca-metabolism is extended toward the highly Ca-exposed space in the mesenchymal portion, along the proximal arterial wall to the peripheral vasculature in tachytrophic organs. |