| Theme |
The impact of bone and Ca/Pi metabolism on vascular disease |
| Title |
The impact of bone and Ca/Pi metabolism on vascular disease |
| Author |
Takashi Shigematsu |
Division of Nephrology and Hypertension, Department of Internal Medicine, Aoto-General Hospital, Jikei University School of Medicine |
| [ Summary ] |
The skeletal system and kidneys have developed in response to the transition from a sea based life to a land based life. A result of this change is a great number of renal failures resulting in the renal osteodystrophy. Bone metabolism related to turnover is not good in renal failure patients. Calcium and phosphorus are released from bone tissue because of failures in the calcium/phosphorus buffering system. Cardiovascular disease is a major problem in renal patients, with calcification of the atherosclerotic vessels being one of a conspicuous features. I would like to propose two concepts: "The renal failure and skeletal failure AXIS" and "The correlation between Bone and Vessels". Recently, the mechanism for vascular calcification has been thought to be quite similar to that for bone formation with calcification. Therefore, I chose, "The relationship between blood vessels and bone" as the main thesis of this issue. |