| Theme |
Cell biology cartilage |
| Title |
The biological action of PTHrP on chondrocytes |
| Author |
Norio Amizuka |
Niigata University Graduate School of Medical and Dental Sciences, Division of Oral Anatomy, Department of Oral Biological Science |
| Author |
Junko Shimomura |
Niigata University Graduate School of Medical and Dental Sciences, Division of Oral Anatomy, Department of Oral Biological Science |
| Author |
Yukie Seki |
Niigata University Graduate School of Medical and Dental Sciences, Division of Oral Anatomy, Department of Oral Biological Science |
| Author |
Takeyasu Maeda |
Niigata University Graduate School of Medical and Dental Sciences, Division of Oral Anatomy, Department of Oral Biological Science |
| [ Summary ] |
Parathyroid hormone-related peptide plays a pivotal role in chondrocyte proliferation and differentiation, as evidenced by the congenital deformities seen in PTHrP deficient mice. Further studies verified that PTHrP could regulate chondrocyte differentiation to hypertrophic phenotype by mediating Indian hedgehog (IHH). The biological action of PTHrP signaling was clinically comfirmed by analyses on Jansen type-/Blomstrand type-chondrodysplasia as well as enchondromatosis that are caused by point mutations in the PTH/PTHrP receptor. A recent study demonstrated that PTH/PTHrP receptor binds to Na+/H+ exchanger regulatory factors (NHERF) through a PDZ-domain, and the complex of the PTH/PTHrP receptor and NHERF activates signaling linked to phospholipase. The cellular and molecular mechanism of chondrocyte proliferation and differentiation is reviewed. |