| Theme |
Recent progress in parathyroid hormone research |
| Title |
Chronic renal failure and parathyroid cell growth |
| Author |
Masanori Tokumoto |
The Kidney Care Unit, University Hospital, Faculty of Medicine, Kyushu University |
| Author |
Masatomo Taniguchi |
The Kidney Care Unit, University Hospital, Faculty of Medicine, Kyushu University |
| Author |
Hideki Hirakata |
The Kidney Care Unit, University Hospital, Faculty of Medicine, Kyushu University |
| [ Summary ] |
It is well known that 1,25 (OH)2 vitamin D3 deficiency, hypocalcemia and phosphate retention play a crucial role in the development of secondary hyperpara thyroidism (2HPT). Recent works have revealed these factors also modulate parathyroid cell growth. Moreover, it has been reported that the reduced expression of specific receptors, such as calcium sensing receptor, vitamin D receptor, also contribute to parathyroid cell growth. However, the sensing mechanisms of phosphate retention remain unknown. For achievement of complete control of 2HPT, the linkage between these receptor abnormalities and parathyroid cell growth should be clarified. |