| Theme |
Recent progress in parathyroid hormone research |
| Title |
Regulators of calcium homeostasis and the renin-angiotensin system |
| Author |
Keiichi Tamagaki |
Division of Hypertension and Kidney Disease, Kyoto Prefectural University of Medicine |
| Author |
Masafumi Fukagawa |
Division of Nephrology and Dialysis Center, Kobe University School of Medicine |
| [ Summary ] |
The renin-angiotensin system is a regulatory cascade that plays an essential role in the regulation of blood pressure, electrolyte, and volume homeostasis. Regulators of calcium homeostasis, such as parathyroid hormone, parathyroid hormone-related peptide and vitamin D, and serum calcium concentration are known to independently influence renin secretion and renin gene expression. Clinical studies have revealed the relationship between the regulators of calcium homeostasis and the pathophysiology of essential hypertension. In a recent few years, studies of animal models and cell models of renin expression have made significant advances in our understanding of renin gene regulation. Furthermore, vitamin D and vitamin D receptor have been shown to play important roles in renin gene transcription. |