| Theme |
Bone disorders in rheumatic diseases |
| Title |
Bone marrow cell development and trabecular bone turnover in the arthritis animal models |
| Author |
Akinori Sakai |
Department of Ortopaedic Surgery, University of Occupational and Environmental Health |
| [ Summary ] |
Adjuvant-induced arthritis and type II collagen-induced arthritis are useful models for the investigation of bone metabolism in arthritis. In arthritis, trabecular bone volume decreases due to enhanced bone resorption and reduced bone formation. Enhanced bone resorption is completely inhibited by the oral administration of indomethacin through the suppression of prostaglandins, but bone formation is not altered. The number of osteogenic cells decreases because of the decreased total bone marrow cells per bone, the osteoblastic differentiation is not affected substantially. The abnormality of osteoclastic cell lineage plays a critical role in bone marrow cell development in arthritis. |