| Theme |
Progress in bone metabolic markers |
| Title |
Type I procollagen propeptide (intact PINP, PICP) |
| Author |
Yoshihito Nishioka |
Research and Development, Clinical Development, Chugai Diagnostics Science Co., Ltd. |
| [ Summary ] |
Bone tissue is made of the hydroxyapatite, which is produced from calcium and phosphate of the bone matrix. More than ninety percent of this bone is composed of Type I collagen.
Type I collagen is first synthesized as Type I procollagen, extra-cellular secretion is the next step in synthesis. The C terminal and N terminal are cut by the action of peptidase. PICP and intact PINP are cut from the N terminal along with the C terminal. Type I collagen produces polymerization and can produce an increase in collagen fibers. In this paper, the clinical usefulness of serum level measurements, in relation to in tact PINP and PICP as formation markers of bone metabolism, were discussed. |