| Theme |
Hyperphosphatemia |
| Title |
Molecular biology of sodium dependent phosphate transporter |
| Author |
Eiji Takeda |
Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| Author |
Megumi Iida |
Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| Author |
Kumi Kobayashi |
Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| [ Summary ] |
Phosphate homeostasis and plasma phosphate concentration depend primarily on the amount of renal typeII phosphate transporter (NPT- 2) that regulate tubular phosphate transport. Expression of NPT-2 on the brush border membrane is regulated by transcriptional level of NPT-2 gene and NPT-2 translocation. The analysis of murine and human 5´-promotor region in NPT-2 gene showed the sequences which bind transcription factors such as vitamin D receptor and others. Regulation by intracellular translocation of NPT-2 by parathyroid hormone has been shown to be mediated by a chloride channel (CLC-5) expressed in renal endosomes. Because the internalization of the NPT-2 is affected in Dent's disease caused by mutations in CLC-5. |