| Theme |
Bone Structure as a Determinant Factor for Strength |
| Title |
Effect of vitamin K2 bone microarchitecture in ovariectomized rats |
| Author |
Taro Mawatari |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University |
| Author |
Hiromasa Miura |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University |
| Author |
Hidehiko Higaki |
Department of Mechanical Engineering, Faculty of Engineering, Kyushu Sangyo University |
| Author |
Takaaki Moro-oka |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University |
| Author |
Tsutomu Kawano |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University |
| Author |
Yukihide Iwamoto |
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] |
Osteoporosis is the morbidity in which the risk of fracture is enhanced due to decrease in bone volume and deterioration of its microstructure. As its evaluation standard, only the measurement of bone mineral density (BMD) has been clinically applied, however it is necessary to further study on bone structure that is considered to greatly effect on mechanical strength. Menatetrenone, a vitamin K2 four isoprene units, has been reported to improve osteoporotic bone loss. The purpose of this investigation was to clarify the effect of menatetrenone on the 3-D trabecular microarchitecture in ovariectomized rats by using micro-CT. In this study we evaluated the effect of menatetrenone on 3-D trabecular microarchitecture in ovariectomized rats. The proximal metaphyseal region of the right tibia was evaluated by micro-CT. A parametric analysis of the reconstructed trabecular volume was carried out using bone volume fractions, the fractal dimension, and the connectivity density. Our results suggest that an 8-week administration of menatetrenone protects against the loss of trabecular bone volume and its connectivity when treatment is begun just after the ovariectomy. |