| Theme |
Calcitonin -- update |
| Title |
The mechanism of calcitonin on bone metabolism |
| Author |
Yasuo Imanishi |
Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine |
| Author |
Masaaki Inaba |
Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] |
Calcitonin, a 32 amino acid peptide hormone Secreted from the thyroid, are well known for its ability to regulate osteoclast function on bone resorption. Recent studies show that calcitonin and its receptor play an important role in bone remodeling. Calcitonin regulates bone resorption by modulating osteoclast function via its receptor on cell surface. Extracellular calcium enables parafollicular cells of the thyroid gland to release calcitonin in response to high concentration of extracellular ionized calcium level. Recently cloned calcium-sensing receptor is a G protein-coupled receptor for sensing external calcium concentration. The receptor is also showed to be expressed in thyroid parafollicular cells. In this review article, the effect of calcitonin on osteoclast and the mechanism of calcitonin secretion on parafollicular cells were discussed. |