| Theme |
Calcitonin -- update |
| Title |
Structure and function of calcitonin and its receptor |
| Author |
Seiji Fukumoto |
Department of Laboratory Medicine, University of Tokyo Hospital |
| [ Summary ] |
Calcitonin was initially identified as a hypocalcemic factor and later turned out to be a neuropeptide as well. Calcitonin gene-related peptide, amylin and adrenomedullin are related peptides to calcitonin and reported to mediate diverse biological functions. Receptors for these peptides constitute a subfamily of G protein-coupled receptors and recently shown to obtain responsiveness to different ligands by interactions with receotor-activity modifying proteins. |