| Theme |
Frontiers in Vitamin D Action |
| Title |
Vitamin D action on parathyroid gland |
| Author |
Shozo Yano |
Division of Dialysis and Metabolism, Kobe University School of Medicine |
| Author |
Tatsuo Tsukamoto |
Third Division, Department of Medicine, Kobe University School of Medicine |
| [ Summary ] |
Vitamin D negatively regulates parathyroid hormone (PTH) synthesis and secretion as well as parathyroid cell growth in patients with chronic renal failure. This feedback action of the active vitamin D metabolites mediates not only through vitamin D receptor as genetic action, but also via serum calcium level, which is another strong regulator through calcium-sensing receptor in parathyroid cells. Here, we review the molecular mechanism and action of vitamin D, including newly developed vitamin D analogs, from the therapeutic view point of renal hyperparathyroidism. |