| [ Summary ] |
Vitamin D has roles in a variety of biological actions such as calcium homeostasis, cell proliferation and cell differentiation to many target tissues. Most of such biological actions of vitamin D are now considered to be exerted through nuclear vitamin D receptor (VDR)-mediated control of target genes. VDR belongs to the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor. For the ligand-induced transactivation of VDR, VDR structure is modulated upon ligand binding, following recruitment of the coactivator complexes. In this review, the strucural alterations of VDR depending ligand types and consequent selective interactions with coactivators are discussed. |