| Theme |
Outcomes of peritoneal dialysis treatment during the past half-century |
| Title |
Mechanism of encapsulating peritoneal sclerosis |
| Author |
Kazuki Katayama |
Department of Respiratory Medicine, Saitama Medical University / Allergy Center, Saitama Medical University |
| Author |
Takehito Kobayashi |
Allergy Center, Saitama Medical University / General Internal Medicine, Saitama Medical University |
| Author |
Makoto Nagata |
Department of Respiratory Medicine, Saitama Medical University / Allergy Center, Saitama Medical University |
| [ Summary ] |
Encapsulating peritoneal sclerosis (EPS) is a fatal complication in patients on peritoneal dialysis, and its frequency of occurrence is 0.9-2.4 % of all peritoneal dialysis patients. Long-term peritoneal dialysis durations, peritonitis complications, acidic/hyperosmolarity glucose dialysate, etc. are involved in its onset. Despite the use of neutral icodextrin dialysate, which has become frequently used in recent years, experiments using rats showed that EPS was associated with peritoneal hyperplasia and eosinophil infiltration.The administration of corticosteroids and surgical therapy is the main treatment for EPS. In recent years, surgical outcomes for this condition have improved and it has become standard treatment in cases of advanced EPS. |