臨牀透析 Vol.33 No.12(1-3-2)


特集名 透析患者向け治療食の最先端
題名 [総論]腸内細菌の重要性 b. 慢性腎臓病患者における腸内細菌と栄養
発刊年月 2017年 11月
著者 佐藤 稔 川崎医科大学腎臓・高血圧内科学
【 要旨 】 尿毒素物質は,腎機能の低下とともに体内に蓄積し臓器障害を引き起こす.慢性腎臓病患者で尿毒素物質濃度を低下させるには,その産生を減少させるのが効率的である.インドキシル硫酸,p-クレシル硫酸などは腸内細菌により産生される.健康状態では,腸内細菌叢は個体の恒常性維持に重要な役割を果たす.慢性腎臓病は腸内細菌叢組成を変化させ,腸管粘膜バリア機能を障害する.これらは尿毒素物質の血中濃度上昇に関与している.また,腸内環境の変化は慢性腎臓病をさらに悪化させる要因となる.腎不全で悪化した腸内環境の改善が,今後の慢性腎臓病の新規治療ターゲットとなる.
Theme Forefront of therapeutic food for dialysis patients
Title Intestinal bacteria and nourishment in CKD patients
Author Minoru Satoh Department of Nephrology and Hypertension, Kawasaki Medical School
[ Summary ] Toxins in the urine accumulate in the body in relation to renal dysfunction and cause organ damage. It is effective to decrease urine toxin production to achieve reductions in serum urine toxin concentrations in chronic kidney disease patients. Indoxyl sulfate and p-cresyl sulfate are produced by intestinal bacteria. The enterobacterial flora play important roles in homeostatic maintenance. Chronic kidney disease status changes enterobacterial flora composition and affects intestinal barrier functions, which leads to increases in uemic toxins. In addition, changes in the enteral environment may becomes factors which worsen chronic kidney disease status. Improvements in the enteral environment made worse by renal insufficiency have become new treatments, options for future chronic kidney disease care.
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