| Theme |
Forefront of therapeutic food for dialysis patients |
| Title |
Intestinal bacteria and nourishment in CKD patients |
| Author |
Minoru Satoh |
Department of Nephrology and Hypertension, Kawasaki Medical School |
| [ Summary ] |
Toxins in the urine accumulate in the body in relation to renal dysfunction and cause organ damage. It is effective to decrease urine toxin production to achieve reductions in serum urine toxin concentrations in chronic kidney disease patients. Indoxyl sulfate and p-cresyl sulfate are produced by intestinal bacteria. The enterobacterial flora play important roles in homeostatic maintenance. Chronic kidney disease status changes enterobacterial flora composition and affects intestinal barrier functions, which leads to increases in uemic toxins. In addition, changes in the enteral environment may becomes factors which worsen chronic kidney disease status. Improvements in the enteral environment made worse by renal insufficiency have become new treatments, options for future chronic kidney disease care. |