| Theme |
The appropriate management for CKD-MBD in the elderly patients |
| Title |
Vascular calcification in CKD-MBD -- a process of premature aging |
| Author |
Atsushi Shioi |
Department of Vascular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] |
Vascular calcification (VC) is an important pathophysiologic component of chronic kidney disease-mineral and bone disorder (CKD-MBD) and is an independent risk factor for the development of cardiovascular disease. VC occurs as a result of two distinct pathologic processes that result in medial (arteriosclerosis) and intimal (atherosclerotic) deposition. VC, a vascular lesion characteristic of the elderly, is accelerated in CKD-MBD, leading to the suggestion that CKD-MBD is a premature aging disorder. Comparative studies with genetically induced progeria syndromes caused by nuclear lamina dysfunction have revealed that accumulation of prelamin A may induce cellular senescence of vascular smooth muscle cells (VSMC), leading to the development of VSMC calcification. This finding may pave the way for the development of novel therapies that target vascular aging. |