| Theme |
Recent evaluation and characteristics for dialysis membranes from biocompatible viewpoints |
| Title |
Relationship between biocompatibility and polyvinylpyrrolidone (PVP) elution from dialysis membrane |
| Author |
Jun Murakami |
Department of Clinical Engineering, Tokyo Women's Medical University |
| [ Summary ] |
Severe adverse reactions such as anaphylactoid shock have been reported in patients receiving hemodialysis using polysulfone (PS) membranes. The number of reports identifying polyvinylpyrrolidone (PVP) eluted from PS membranes as the cause of severe anaphylactoid shock is limited. In this paper, we mention the biocompatibility of dialysis membranes based on our study of structural changes in PVP due to sterilization. Furthermore, we introduce important factors to avoid severe adverse reactions due to the biocompatibility of dialysis membranes in typical hemodialysis treatments. |