| Theme |
The initiation and maintenance of dialysis in terms of original kidney diseases and complications |
| Title |
Initiation and maintenance of renal replacement therapy in patients with refractory nephrotic syndrome |
| Author |
Yusuke Watanabe |
Department of Nephrology, Saitama Medical University / Division of Dialysis Center and Department of Nephrology, Saitama Medical University International Medical Center |
| Author |
Hirokazu Okada |
Department of Nephrology, Saitama Medical University |
| [ Summary ] |
Patients with refractory nephrotic syndrome, especially focal segmental glomerulosclerosis (FSGS) have poor renal prognoses and are prone to end stage renal disease. Massive proteinuria causes hypoalbuminemia leading to severe fluid retention. In most cases, the initiation of renal replacement therapy is required to remove excess fluid retention. Hemodialysis, peritoneal dialysis and renal transplantation are also good treatment choices. The incidence of recurrent FSGS in renal allograft recipients is generally accepted to be 30 %. Once it recurs, however, the prognosis for renal graft patients is poor. |