臨牀透析 Vol.29 No.8(5-6-3)


特集名 透析患者の栄養障害とNSTの可能性
題名 規模別NST活動の展開 (6) 各種特殊な病態を有する患者 3. 壊疽
発刊年月 2013年 07月
著者 高橋 聖子 湘南鎌倉総合病院栄養管理センター・NST専門療法士
著者 日高 寿美 湘南鎌倉総合病院腎臓病総合医療センター血液浄化部
著者 小林 修三 湘南鎌倉総合病院腎臓病総合医療センター副院長(NSTチェアマン)
【 要旨 】 下肢壊疽を有する透析患者に対しては,十分なエネルギー・たんぱく質を摂取し,除脂肪体重を維持しなければ,創傷治癒は難しい.さらに,アルギニン,グルタミン,HMB投与が創傷治癒には有効である.当院では,フットカンファレンスで取り上げられた症例が自動的にNST(nutrition support team)介入となるシステムを構築している.NSTが介入した下肢壊疽のある透析患者を後方視的に死亡群と生存群で比較すると,死亡群はNST介入終了時でCRPが高値であり,感染のコントロールが困難であった可能性が示唆された.
Theme Protein-energy wasting and potentiality of NST in dialysis patients
Title Nutrition disorder of dialysis patients (particularly gangrene patients) and the possibility of nutrition support team
Author Seiko Takahashi Department of Nutrition, Shonan Kamakura General Hospital
Author Sumi Hidaka Department of Blood Purification, Shonan Kamakura General Hospital
Author Shuzo Kobayashi Kidney Disease and Transplant Center, Shonan Kamakura General Hospital
[ Summary ] Patients undergoing maintenance dialysis are always in hypermetabloic and catabolic states. Any significant wound leads to the patient being in a much more catabolic state with nutritional needs being significantly increased. Wound healing is directly related to the degree of lean body mass (LBM) loss. Therefore, optimum nutrition is well recognized as a key factor in maintaining wound healing. Arginine, glutamine, and HMB are effective in promoting wound healing. We established a system that allows NSTs to intervene automatically after patients are discussed at foot conferences. In order to retrospectively evaluate clinical data concerning patients undergoing hemodialysis with gangrene in their legs, we divided these patients into two groups. They were the survival and non-survival groups, used to compare the serum levels of albumin, transthyretin, and CRP, along with actual intake of energy and protein. The non-survival group showed significantly higher CRP levels after NST intervention. Therefore, the control of infection may be considered a very important issue. Energy and protein intakes were less in both groups as compared to recommendation guidelines. We must make plans to increase energy and protein intake for patients with gangrene who are undergoing hemodialysis therapy.
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