| Theme |
Problems to be solved in the therapy for renal anemia : Association of ESA hyporesponsiveness with dysregulated iron metabolism |
| Title |
Appropriate iron therapy dosages |
| Author |
Rika Yamazoe |
Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University |
| Author |
Kenichiro Kitamura |
Department of Nephrology, Graduate School of Medical Sciences, Kumamoto University |
| [ Summary ] |
Iron deficiency is one of the most common problems for patients with chronic kidney diseases. An imbalance in iron levels may result due to various reasons. These include potential limitations on iron intake in dietary therapy, dysfunction of iron metabolism, an increases in iron consumption following ESA administration, as well as blood loss in dialysis circuits. Therefore, iron administration is critical for effective treatment of renal anemia. On the other hand, an excessive dosage of iron may lead to increased oxidative stress. It may also be associated with infections or atherosclerosis. Based on the pros and cons of iron therapy, we investigated effective intravenous iron administration frequency to reduce oxidative stress. We describe safe dosages of iron in terms of administration frequency. |