臨牀透析 Vol.29 No.11(2-3)


特集名 わが国におけるAKI診療の現状と課題
題名 ［各論］薬剤性AKIの早期診断と予防法
発刊年月 2013年 10月
著者 森 潔 京都大学大学院医学研究科メディカルイノベーションセンター
著者 桒原 孝成 京都大学大学院医学研究科内分泌代謝内科
著者 横井 秀基 京都大学大学院医学研究科内分泌代謝内科
著者 笠原 正登 京都大学大学院医学研究科内分泌代謝内科
著者 向山 政志 京都大学大学院医学研究科内分泌代謝内科
著者 中尾 一和 京都大学大学院医学研究科内分泌代謝内科
【 要旨 】 本稿では，薬剤性腎障害の分類について総括し，抗癌剤・抗菌薬・非ステロイド系消炎鎮痛薬によるAKIの新規バイオマーカーを用いた早期診断，薬物モニタリング，補液によるAKIの予防などについてAKI診療の現状を考察する．
Theme Current trends and issues for medical management of acute kidney injury in Japan
Title Early diagnosis and prevention of drug-induced AKI
Author Kiyoshi Mori Medical Innovation Center, Kyoto University Graduate School of Medicine
Author Takashige Kuwabara Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
Author Hideki Yokoi Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
Author Masato Kasahara Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
Author Masashi Mukoyama Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
Author Kazuwa Nakao Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine
[ Summary ] Novel biomarkers have emerged for the early diagnosis of AKI, primarily through experiments in animals. The usefulness of these is currently being evaluated in various clinical settings. In this article, we briefly review the characteristics of drug-induced kidney damage and discuss 1) early diagnosis of AKI induced by anti-cancer drugs, antibiotics and NSAIDs using novel AKI biomarkers, 2) therapeutic drug monitoring, and 3) prevention of AKI with hydration.
戻る