| Theme |
Prospects for Hemodiafiltration |
| Title |
Enhancement of solute removal through improvements in peripheral circulation |
| Author |
Kei Eguchi |
Department of Clinical Engineering, Tokyo Women's Medical University |
| Author |
Tetsuya Matsushima |
Nishijin Clinic |
| [ Summary ] |
In order to remove toxins effectively from the entire body, it is important to maintain peripheral circulation during hemodialysis treatment. Solute transfer between intra- and extravascular compartments must be maintained also. Intermittent infusion hemodiafiltration (I-HDF) and physical exercise during hemodialysis treatment have recently been introduced and been found effective in enhancing solute removal through improvements in peripheral circulation. I-HDF improves peripheral capillary circulation. This improvement is achieved by repeated intermittent infusion, resulting in incrementally normalizing amounts removed not only of small sized solutes but also low molecular weight proteins in approximately half of the cases. Physical exercise during hemodialysis treatment is also effective in increasing muscle blood volume and normalizing quantities of β2-MG removed. |