| Theme |
New Perspectives of Molecular Biomarker in Dialysis Therapy |
| Title |
Genome study on dialysis patients |
| Author |
Kent Doi |
Department of Hemodialysis & Apheresis, and Nephrology & Endocrinology, University of Tokyo |
| Author |
Eisei Noiri |
Department of Hemodialysis & Apheresis, and Nephrology & Endocrinology, University of Tokyo |
| [ Summary ] |
The genome-based study of human disease has developed rapidly with the completion of the human genome project and the remarkable concomitant progress of technology. Genome-wide association studies (GWAS) are expected to reveal novel susceptibility genes which are responsible for multifactorial diseases such as hypertension and diabetes. So far, genomic studies on dialysis patients employing candidate gene approaches have identified several susceptible genes related to progression of renal diseases and cardiovascular complications, although the statistical powers of these studies are not sufficient. Further investigations are necessary to confirm the previously identified susceptibility genes. Recent technological advances will enable us to perform GWAS more easily and establish novel treatment strategies based on genomic information related to kidney disease. |