| Theme |
Acute Blood Purification Therapy |
| Title |
Strategy of dosage adjustment during CRRT |
| Author |
Takehito Yamamoto |
Department of Pharmacy, The University of Tokyo Hospital, The University of Tokyo |
| Author |
Yoshiyuki Ohno |
Department of Pharmacy, The University of Tokyo Hospital, The University of Tokyo |
| Author |
Akihiro Hisaka |
Pharmacology and Pharmacokinetics, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo Hospital, The University of Tokyo |
| Author |
Hiroshi Suzuki |
Department of Pharmacy, The University of Tokyo Hospital, The University of Tokyo |
| [ Summary ] |
It is well known that the pharmacokinetics of drugs which are mainly excreted via the kidneys, is altered during continuous renal replacement therapy (CRRT). This is especially problematic when setting the dosage of antibiotics and antiarrhythmic drugs for patients receiving CRRT because many of these drugs are excreted primarily via the kidneys. In general, dosage during CRRT should be set to be the same as the dosage for patients with moderately impaired renal functions (i. e. creatinine clearance (CLcr) of 10-50 ml/min), because CRRT accounts for CLcr of 10-30 ml/min. However, dosage adjustment is required in some cases in relation to the pharmacokinetic properties of drugs. Therefore, in addition to understanding the above mentioned principles, reported clinical evidence also should be considered when adjusting dosage during CRRT. |