臨牀透析 Vol.24 No.8(8)


特集名 透析患者の呼吸器合併症
題名 薬剤誘起性肺炎/血管炎と肺病変
発刊年月 2008年 07月
著者 米田 雅美 東京女子医科大学東医療センター内科
著者 内藤 隆 東京女子医科大学東医療センター内科
著者 佐藤 まどか 東京女子医科大学東医療センター内科
著者 伊田 陽一 東京女子医科大学東医療センター内科
著者 山中 智恵 東京女子医科大学東医療センター内科
著者 佐中 孜 東京女子医科大学東医療センター内科
【 要旨 】 薬剤誘起性肺炎は種々の検査をもってしても確定診断はつけ難く,まず疑いをもち問診や経過を追うことが肝要である.早期診断,早期治療が求められる.その多くは間質性肺炎であり,治療としてステロイド薬や免疫抑制薬が中心となるが,新たにアフェレシス療法介入の余地はあるかもしれない.血管炎の肺病変の多くも間質性肺炎であるが,生命予後を左右する重篤な肺病変としては肺出血が挙げられる.肺出血の多くは血管炎のなかでも顕微鏡的多発血管炎 (microscopic polyangiitis ; MPA) に見受けられ,myeloperoxidase (MPO) - 抗好中球細胞質抗体(antineutrophil cytoplasmic antibody ; ANCA) が関連する.MPO-ANCA関連血管炎は急速進行性糸球体腎炎を発症する疾患として有名であるが,その死因の第1位は感染症,第2位が肺出血,第3位が腎不全となっている.治療としてはステロイド薬や免疫抑制薬が中心となるが,アフェレシス療法の併用も多施設で行われている.
Theme Complications of Respiratory Organs in Dialysis Patients
Title Drug-induced pneumonitis and lung disease associated with vasculitis
Author Masami Komeda Internal Medicine, Tokyo Women's Medical University Medical Center East
Author Takashi Naito Internal Medicine, Tokyo Women's Medical University Medical Center East
Author Madoka Satou Internal Medicine, Tokyo Women's Medical University Medical Center East
Author Youichi Ida Internal Medicine, Tokyo Women's Medical University Medical Center East
Author Chie Yamanaka Internal Medicine, Tokyo Women's Medical University Medical Center Eastl
Author Tsutomu Sanaka Internal Medicine, Tokyo Women's Medical University Medical Center East
[ Summary ] It is difficult to formulate a definite diagnosis of drug-induced pneumonitis even after performing a number of examinations. It is therefore important to suspect the presence of a causative drug and to investigate causative relationships through interviews and to follow the patient's clinical course. Early diagnosis and early treatment are required for proper treatment. In many cases, drug-induced pneumonitis is manifested as interstitial pneumonitis, which is usually treated with steroids and immunosuppressive agents. In some cases, there may be room for apheresis therapy intervention in addition to those drugs. In addition, the typical pulmonary manifestation of vasculitis is interstitial pneumonitis. However, pulmonary hemorrhaging may occur in association with vasculitis, resulting in a serious, life-threatening condition. Vasculitis-related pulmonary hemorrhaging is often observed in patients with microscopic polyangiitis (MPA), which is associated with myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO -ANCA). Although MPO-ANCA-associated vasculitis is known to cause rapidly progressive glomerulonepliritis, the leading cause of death in patients with MPO-ANCA-associated vasculitis is infection, followed by pulmonary hemorrhaging and renal failure. MPO-ANCA-associated vasculitis is treated primarily with steroids and immunosuppressive agents, but apheresis therapy is concomitantly performed at many institutions.
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