| 特集名 | 本邦のCAPD療法の現況 | |
|---|---|---|
| 題名 | 本邦CAPD患者の現況 (5) 使用透析液の実態と効果の検証 i. 中性透析液 | |
| 発刊年月 | 2008年 02月 | |
| 著者 | 伊藤 孝史 | 島根大学医学部附属病院腎臓内科 |
| 【 要旨 】 | 腹膜透析を長期に継続するためには，除水不良などの腹膜機能低下および腹膜硬化症などの形態学的変化をいかに抑えるかということが大きな課題である．従来の酸性透析液は，低pH，高ブドウ糖濃度，高浸透圧，ブドウ糖分解産物 (GDPs) などの生体適合性の低さが腹膜にさまざまな悪影響を与えることが証明されてきた．そこで，本邦でもより生体適合性を向上させた中性透析液が開発・発売され，短期投与のみならず，長期投与の有効性を証明する報告も散見されるようになり，さらなる腹膜透析の普及が期待される． | |
| Theme | Present Status of Peritoneal Dialysis in Japan | |
|---|---|---|
| Title | Neutralized peritoneal dialysis solutions | |
| Author | Takafumi Ito | Section of Nephrology, Department of Internal Medicine, Shimane University Faculty of Medicine |
| [ Summary ] | It is a major challenge to reduce peritoneal dysfunction (loss of ultrafiltration) and morphological changes (peritoneal sclerosis) in patients on long-term peritoneal dialysis (PD). There is accumulating evidence that the bioincompatibility of conventional PD solutions (due to a low pH, high glucose concentration, hyperosmolality, and glucose degradation products) leads to adverse effects on the peritoneum. As a result of increased awareness about the unwanted effects of conventional PD solutions, neutral PD solutions with improved biocompatibility have been developed and marketed in Japan. Several studies have demonstrated both short-term and long-term beneficial effects of neutral PD solutions. Accordingly, increased use of such PD solutions is expected. |
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