臨牀透析 Vol.24 No.12(4-5)


特集名 透析患者における循環器合併症ガイドラインを考える
題名 透析患者のおもな循環器合併症 (5) 脳血管障害
発刊年月 2008年 11月
著者 内山 真一郎 東京女子医科大学医学部神経内科学
著者 丸山 健二 東京女子医科大学医学部神経内科学
【 要旨 】 慢性腎臓病は脳卒中の危険因子であり,腎機能が低下するほど脳卒中のリスクが高まるので,透析患者の脳卒中リスクは著しく高い.以前は透析患者では非透析患者と比べて脳梗塞とくも膜下出血の比率が低く,脳出血の比率が高かったが,近年は脳出血が減少し,脳梗塞が増加しつつある.透析患者の脳卒中予防には,生活習慣の改善 (禁煙,減塩,肥満の改善,節酒) と血圧の厳格な管理が推奨される.血圧の管理目標は130 / 80 mmHg未満であり,糖尿病患者では血糖とHbA1cの厳格な管理が推奨される.透析患者は脳出血のリスクが高いので,抗血栓療法や血栓溶解療法の適応には慎重な配慮が求められる.
Theme Buildup of the Guidelines for Cardiovascular Complications of Chronic Dialysis Patients
Title Cerebrovascular disease in chronic kidney disease
Author Shinichiro Uchiyama Department of Neurology, Tokyo Women's Medical University
Author Kenji Maruyama Department of Neurology, Tokyo Women's Medical University
[ Summary ] Chronic kidney disease (CKD) is a risk factor for strokes. As renal function decreases, stroke risk increases. Therefore, hemodialysis patients are at very high risk of stroke. In the past, the percentages of cerebral infarction and subarachnoid hemorrhage were lower and those for cerebral bleeding was in patients with than without hemodialysis. In recent years, however, cases of cerebral bleeding have declined and the number of cerebral infarctions has increased. For stroke prevention in dialysis patients, life style modification including smoking cessation, salt intake limitation, reducing body weight, and avoiding excess alcohol consumption, as well as strict management of blood pressure is recommended. Target blood pressure should be below 130 / 80 mmHg. Strict management of blood glucose and hemoglobin A1c levels is also recommended in diabetic patients. Since dialysis patients are at high risk of cerebral hemorrhage, decision making for indications of antithrombotic and thrombolytic therapies should be very caucious.
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