| Theme |
Issues of Evidence-based Adequate Dialysis Therapy |
| Title |
Peritoneal dialysis fluids (PDF) and biocompatibility |
| Author |
Masahito Tamura |
Kidney Center, University of Occupational and Environmental Health University Hospital |
| Author |
Narutoshi Kabashima |
Kidney Center, University of Occupational and Environmental Health University Hospital |
| Author |
Ryota Serino |
Department of Cardiology and Nephrology, University of Occupational and Environmental Health University Hospital |
| Author |
Tatsuya Shibata |
Department of Cardiology and Nephrology, University of Occupational and Environmental Health University Hospital |
| Author |
Tetsu Miyamoto |
Department of Cardiology and Nephrology, University of Occupational and Environmental Health University Hospital |
| Author |
Yutaka Otsuji |
Department of Cardiology and Nephrology, University of Occupational and Environmental Health University Hospital |
| [ Summary ] |
Patients treated with peritoneal dialysis are at risk for development of ultrafiltration failure due to morphologic changes in the peritoneum, such as fibrosis and new vessel formation. The bioincompatibility of conventional PDFs has been attributed to the presence of non-physiological components such as high concentrations of glucose and degenerative products such as glucose degradation products (GDPs) as well as advanced glycation end products (AGEs), hyperosmolality, low pH, and lactates. To improve the biocompatibility of PDF, newly formulated second-generation fluids, with neutral pH levels, along with two chamber bags or PDF containing icodextrin as an alternative osmotic agent have been developed. Recent basic and clinical research has elucidated that these new PDFs are superior to conventional PDFs in terms of biocompatibility. |