| Theme |
Metabolic Syndrome in Chronic Renal Failure |
| Title |
Glucose intolerance in dialysis patients : relationship to metabolic syndrome |
| Author |
Toshiyuki Nakao |
Department of Nephrology, Tokyo Medical University |
| Author |
Hiroshi Matsumoto |
Department of Nephrology, Tokyo Medical University |
| Author |
Toshikazu Wada |
Department of Nephrology, Tokyo Medical University |
| [ Summary ] |
Although atherosclerotic diseases are prevalent in chronic dialysis patients, the mechanisms of atherosclerosis affecting those patients may not entirely be explained in terms of metabolic syndrome. Abnormal glucose and lipid metabolism in dialysis patients with end-stage renal failure is very similar to that seen in metabolic syndrome. Obesity is not always the cause of those abnormal metabolic conditions in dialysis patients.
Glucose intolerance is diagnosed by plasma glucose levels both in a fasting state and at 2 hours after a 75 g glucose ingestion, and are classified into normal, equivocal or diabetic types. Even in obese dialysis patients, weight reduction for glycemic control may not necessarily produce favorable outcomes. Serum glycated albumin has recently been noted as an indicator of long-term glycemic control in dialysis patients, though a strict criteria for glycemic control in those patients has not yet been clarified. |