| [ Summary ] |
An ultrafiltrate obtained at flow rates of 7 ml / min by continuous hemofiltration was introduced into a hollow fiber module, in which proximal tubular epithelial cells were grown on the inner surfaces. The filtrate water was actively transported to the patient's blood across the cell-attached hollow fiber membranes at the rate of 4 ml / min, 3 ml / min of the filtrate was discarded since the same amount would be replaced by drinking and meals. A bioartificial tubule device with a membrane area of 0.8 m2 can transport 6 l of water, sodium and glucose solution over 24 hours.
A continuous hemofilter with a membrane area of 0.2-0.3 m2, which can receive filtrate from a patient at the rate of 7 ml / min, may be kept in a vest pocket. A double headed Watson-Marlow tube pump (WM-313), put in a lumber pouch or a back pack, can control the blood flow rate of 100 ml / min and a filtration rate of 7 ml / min at the same time. |