| 特集名 | 生体適合面からみた透析機器 | |
|---|---|---|
| 題名 | 生体適合性マーカーとしてのネオプテリンの有用性 | |
| 発刊年月 | 2004年 05月 | |
| 著者 | 吉田 克法 | 奈良県立医科大学附属病院泌尿器科透析部 |
| 【 要旨 】 | 長期透析に伴う合併症発現に関して，透析機器の生体適合性は重要な問題である．生体適合性のマーカーは種々報告されているが，血清ネオプテリンの有用性について検討した．ネオプテリンは，種々の刺激により活性化されたTリンパ球より分泌されたgamma-IFNの影響で，おもにマクロファージより産生される．透析膜を含む体外循環において，イヌを用いた実験的検討においても，また透析患者における臨床的検討においても，体外循環経過とともに血清ネオプテリンは上昇し，生体適合性マーカーとしての有用性が示唆された．このネオプテリンを用いて種々の透析膜の生体適合性評価に役立つものと判断される． | |
| Theme | Biocompatibility on Materials for Dialysis Equipments and Devices | |
|---|---|---|
| Title | Serum neopterin as marker for hemodialysis biocompatibility | |
| Author | Katsunori Yoshida | Division of Dialysis Unit, Department of Urology, Nara Medical University Hospital |
| [ Summary ] | One complication with long term hemodialysis is the biocompatibility of dialysis-membranes. Markers of hemodialysis biocompatibility have been reported in various ways, and at this time the utility of serum neopterin has been evaluated. Neopterin can leave products from the macrophages due to the influence of gamma-IFN secreted by T-lymphocytes, which are revitalized by various forms of stimulation. An experiment concerning extracorporeal circulation, useing a membrane, was performed in order to evaluate changes in neopterin in dogs. Furthermore, a similar trial was done with a dialysis patient. Serum neopterin rose with the progress of extracorporeal circulation, the utility of neopterin as a biocompatibility marker was suggested. It was also suggested that neopterin was useful for biocompatibility evaluation of dialysis membranes. |
|