| 特集名 | 透析アミロイド症 -- 今日の考え方 | |
|---|---|---|
| 題名 | 透析アミロイド症の発症メカニズム (2) 修飾されたbeta2-microglobulin | |
| 発刊年月 | 2004年 02月 | |
| 著者 | 小川 洋史 | 新生会第一病院内科 |
| 【 要旨 】 | 透析アミロイド症のアミロイド線維蛋白は，beta2-microglobulin (beta2-m) と下条らにより報告されたが，詳細な線維形成メカニズムはまったく解明されていない．beta2-mはserum amyloid A proteinと同じくbetaシート構造を有し，アミロイド線維化をきたしやすい性質がある．native beta2-mのほかに，acidic beta2-mやtruncated beta2-m，advanced glycation endproduct beta2-m (AGE beta2-m) が報告され，amyloidgenesityについて検討されてきた．本稿では主として，修飾されたbeta2-m (modified beta2-m) について述べる． | |
| Theme | Dialysis Amyloidosis -- Present State of the Art | |
|---|---|---|
| Title | Beta2-microglobulin modified | |
| Author | Hiroshi Ogawa | Department of Internal Medicine, Shinseikai Dai-ichi Hospital |
| [ Summary ] | Gejyo et al. have reported that the amyloid fibril protein associated with dialysis-related amyloidosis is beta2-microglobulin (beta2-m). However, the detailed mechanism of amyloid fibril formation remains to be clarified. beta2-m has the same beta-plated structure as serum amyloid A protein, and can readily form amyloid fibrils. Acidic beta2-m, truncated beta2-m and the advanced glycation end product beta2-m, as well as native beta2-m, were reported to be modified forms of beta2-m, and were investigated as to amyloidgenesity. Modified beta2-m is described in this chapter. | |